About Profile

Dr. Saurav Jyoti Patgiri joined the institute in 2016 and works primarily on malaria research and other infectious diseases. He has worked on genetic diversity and drug resistance markers of malaria and has generated data on molecular diversity of Plasmodium falciparum genes. He has also worked on novel synthetic compounds showing anti-malarial activity. In addition, he has helped in the co-development of rapid point of care diagnostics for Plasmodium species and also C580Y SNP based assay for detecting artemisinin resistance. He is currently part of an ICMR task force project on melioidosis and the PI of the Nodal centre here at ICMR-RMRCNE for all the eight states of NE India. In addition, he also lends his support to the bacteriology lab for culture identification and interpretation of anti-microbial sensitivity results. He was involved in the development of a mobile application named MoSQuIT for surveillance of malaria along the international border districts of Northeast India. Apart from malaria, he has also worked on Zika and Dengue virus surveillance in mosquito vectors in this region and has incriminated Ae. albopictus and Ae. aegypti as DENV vectors in four northeastern states for the first time. He has taken part in a number of outbreak investigations such as Dengue, diarrhoeal diseases and acute haemorrhagic conjunctivitis. He is actively involved in institutional activities such as organization of various events, conducting interviews for project staff, member in a number of committees, etc. He is also the Research Integrity Officer of the institute and the Nodal Officer for ICMR-iRISE initiative for equipment sharing.

Area of Interest

Medical Microbiology, Malaria Research, Molecular Biology & Bioinformatics

Research Experience

In the field of malaria research, he is involved in a number of studies on real-time surveillance of malaria in international border districts of NE India, molecular characterization of malarial parasites and drug resistance genes and studies on specific vaccine candidate gene polymorphisms. He has demonstrated the feasibility of real-time surveillance data transmission through mobile apps in Tripura, Assam and Arunachal Pradesh. He has identified several novel haplotypes in Plasmodium falciparum drug resistance genes from Tripura and Assam. In addition to malaria, he has worked on a number of other infectious diseases like TB, Zika virus, Covid-19, Dengue, bacterial diseases, etc. and participated in outbreak investigations supporting the local administration and health departments.

Awards & Acheivements

• 2001 - Secured 15th position in all Assam rankings (SEBA) in HSLCE (Matriculation)
• 2003 - Secured 3rd position in all Assam rankings (AHSEC) in HSSLCE (10+2)
• 2008 - Secured 1st position in Final MBBS examinations, Assam Medical College under Dibrugarh University
• 2011 - Received DBT M.D. /M.S. Thesis grant for thesis titled “A study of the viral aetiology of Acute Encephalitis Syndrome cases with special reference to Japanese Encephalitis-a hospital based study”. (DBT Sanction NO. BT/Med/15/Vision-NER/2011, Date: November 2nd 2011)

Professional Experience

• 2024 – Till date Sci-E, ICMR-RMRCNE, Dibrugarh, Assam
• 2020 – 2024 Sci-D, ICMR-RMRCNE, Dibrugarh, Assam
• 2016 – 2020 Sci-C, ICMR-RMRCNE, Dibrugarh, Assam
• 2013 – 2016 Research Scientist-II, Assam Medical College, Dibrugarh, Assam
• 2009 – 2010 Medical Officer, NHM, Assam.

Publications

• Patgiri SJ, Gohain GG, Goswami SK, Bhattacharyya DR, Debnath SHD, Panat L, et al. Development and On-Field Deployment of a Mobile-Based Application MoSQuIT for Malaria Surveillance in International Border Districts of Northeast India: Challenges and Opportunities. International Journal of Environmental Research and Public Health. 2022;19(5):2561.
• Patgiri SJ, Sarma K, Sarmah N, Bhattacharyya N, Sarma DK, Nirmolia T, et al. Characterization of drug resistance and genetic diversity of Plasmodium falciparum parasites from Tripura, Northeast India. Sci Rep. 2019; 9 (1):13704.
• Saurav Jyoti Patgiri, Dibya Ranjan Bhattacharyya, Ipsita Pal Bhowmick, Md. Atique Ahmed. Deciphering asymptomatic malaria – the missing link in India’s fight against the disease? Curr. Sc(3)i. 2020 May; 118(9): 1333-34.
• Nirmolia T, Ahmed MA, Sathishkumar V, Sarma NP, Bhattacharyya DR et al. Genetic diversity of Plasmodium falciparum AMA-1 antigen from the Northeast Indian state of Tripura and comparison with global sequences: implications for vaccine development. Malaria journal 2022;21(1):62.
• Ahmed, M.A.; Baruah, P.; Saif, A.; Han, J.-H.; Al-Zharani, M.; Wazid, S.W.; Alkahtani, S.; Patgiri, S.J.; Al-Eissa, M.S.; Quan, F.-S. In Silico Analysis Reveals High Levels of Genetic Diversity of Plasmodium knowlesi Cell Traversal Protein for Ookinetes and Sporozoites (PkCelTOS) in Clinical Samples. Tropical Medicine and Infectious Disease 2023, 8, 380.
• Rajkonwar, J.; Shende, V.; Maji, A.K.; Pandey, A.; Sharma, P.K.; Gunasekaran, K.; Subbarao, S.K.; Bhattacharyya, D.R.; Raghavendra, K.; Pebam, R.; et al. First Report of Anopheles annularis s.l., An. maculatus s.s., and An. culicifacies s.l. as Malaria Vectors and a New Occurrence Record for An. pseudowillmori and An. sawadwongporni in Alipurduar District Villages, West Bengal, India. Microorganisms 2024, 12, 95.
• Borgohain P, Shakya A, Ghosh SK, Gogoi N, Patgiri SJ, Bhowmick IP, et al. Design, in silico study, synthesis and evaluation of hybrid pyrazole substituted 1,3,5-triazine derivatives for antimalarial activity. Experimental parasitology. 2024;261:108767.
• Adhikari N, Choudhury AAK, Shakya A, Ghosh SK, Patgiri SJ, Singh UP, et al. Design and development of novel N-(4-aminobenzoyl)- l-glutamic acid conjugated 1,3,5-triazine derivatives as Pf-DHFR inhibitor: An in-silico and in-vitro study. Journal of Biochemical and Molecular Toxicology. 2023;37(4):e23290.
• Choudhury AAK, Vinayagam S, Adhikari N, Saha A, Ghosh SK, Bhat HR, et al. Hybrid PABA-glutamic acid conjugated 1,3,5-triazine derivatives: Design, synthesis, and antimalarial activity screening targeting Plasmodium falciparum dihydro folate reductase enzyme. Chemical Biology & Drug Design. 2023;102(6):1336-52.
• Saha A, Choudhury AAK, Adhikari N, Ghosh SK, Shakya A, Patgiri SJ, et al. In silico screening, synthesis, and antimalarial evaluation of PABA substituted 1,3,5-triazine derivatives as Pf-DHFR inhibitors. Experimental parasitology. 2023;250:108546.
• Saha A, Choudhury AAK, Adhikari N, Ghosh SK, Shakya A, Patgiri SJ, et al. Molecular docking and antimalarial evaluation of hybrid para-aminobenzoic acid 1,3,5 triazine derivatives via inhibition of Pf-DHFR. Journal of Biomolecular Structure and Dynamics. 2023;41(24):15520-34.
• Patgiri SJ, Mazumdar H, Saikia L. Seroprevalence of Cysticercus Antibodies in Japanese Encephalitis Patients in Upper Assam, India: A Hospital Based Study. J Clin Diagn Res. 2016;10(5):Dc21-3.
• Das A, Patgiri SJ, Saikia L, Dowerah P, Nath R. Bacterial Pathogens Associated with Community-acquired Pneumonia in Children Aged Below Five Years. Indian Pediatr. 2016;53(3):225-7.
• Boro P, Gongo T, Ori K, Kamki Y, Ete N, Jini M, et al. An outbreak of acute hemorrhagic conjunctivitis due to Coxsackievirus A24 in a residential school, Naharlagun, Arunachal Pradesh: July 2023. Indian journal of medical microbiology. 2024;48:100549.
• Bora K, Pagdhune A, Patgiri SJ, Barman B, Das D, Borah P. Does social media provide adequate health education for prevention of COVID-19? A case study of YouTube videos on social distancing and hand-washing. Health Educ Res. 2022;36(4):398-411.
• Kumar NP, Kumar A, Panneer D, Abidha S, Muthukumaravel S, Sankari T, et al. Nation-wide vector surveillance on Zika and Dengue did not indicate transmission of the “American lineage pandemic ZIKA virus” in India. International Journal of Infectious Diseases. 2021.
• Boruah DK, Marak R, Bhuyan D, Mazumdar H, Patgiri SJ. Importance of 1H-MR spectroscopy of the brain to identify the minimal hepatic encephalopathy in different patients with liver cirrhosis: A prospective study. J Neurosci Rural Pract. 2024;15:245-54.
• Bishwal SC, Das MK, Badireddy VK, Dabral D, Das A, Mahapatra AR, Sahu S, Malakar D, Singh II, Mazumdar H, Patgiri SJ, Deka T, Kapfo W, Liegise K, Kupa RU, Debnath S, Bhowmik R, Debnath R, Behera RK, Pillai MG, Deuri P, Nath R, Khalo KP, Sing WA, Pandit B, Das A, Bhattacharya S, Behera D, Saikia L, Khamo V, Nanda RK. Sputum Proteomics Reveals a Shift in Vitamin D-binding Protein and Antimicrobial Protein Axis in Tuberculosis Patients. Sci Rep. 2019;9(1):1036.
• Arya R, Dabral D, Faruquee HM, Mazumdar H, Patgiri SJ, Deka T, et al. Serum Small Extracellular Vesicles Proteome of Tuberculosis Patients Demonstrated Deregulated Immune Response. Proteom Clin Appl 2019;0(ja):1900062.
• Sumi Chetry, Saurav Jyoti Patgiri, Dibya Ranjan Bhattacharyya, Prafulla Dutta and N. Pradeep Kumar. Incrimination of Aedes aegypti and Aedes albopictus as vectors of dengue virus serotypes 1, 2 and 3 from four states of Northeast India. Access Microbiology 2020; 2.
• Patgiri SJ, Borthakur AK, Borkakoty B, Saikia L, Dutta R, Phukan SK. An appraisal of clinicopathological parameters in Japanese encephalitis and changing epidemiological trends in upper Assam, India. Indian journal of pathology & microbiology. 2014;57(3):400-6.
• Rahman M, Sharma A, Patgiri S, Hussain E, Borah AK, Saikia L. Serotyping of dengue viruses circulating during 2014-2015 in Assam, India. Indian journal of medical microbiology. 2018;36(3):429-31.

Projects

• Vector surveillance for ZIKV in selected high-risk areas in India.
• Malaria Evolution in South Asia.
• ‘MISSION’: A Multi-Centric Capacity Building Initiative to Strengthen the Clinical and Laboratory Detection of MelioidoSis in India with special fOcus on the North Eastern States.
• Linking parasite drug resistance and genetic diversity to host genetic and metabolic factors – lead for improved therapeutic efficacy in malaria.
• Role of Merozoite surface protein (MSP) triggered CD4, CD8 derived cytokines in malaria in pregnancy.
• Design, Microwave Assisted Synthesis and Antimalarial Evaluation of Hybrid Para-Amino- Benzoic Acid- 1,3,5-triazine derivatives.
• Novel malaria surveillance system along international borders to North-east India using mobile platforms
• Molecular Epidemiology of Malaria in India and Qatar with an emphasis on Parasite diversity, drug resistance and Immune response

Staff

Details of current Project Staff (2024) working under the guidance of Dr Saurav J. Patgiri:

1. Anukalpa Saikia, PTS-III
2. Sushmita Yadav, PTS-III
3. Mondip Deori, PTS-II
4. Jyotirmoy Das, PTS-III
5. Rajiv Nath, PTS-II