About Profile

I am an immunologist interested in understanding the fine tuning of T cell response that keeps the pathogen in check without or with minimal damage to self during infection and additionally, assessing the therapeutic potential of immunoregulatory cells in reducing intestinal inflammation.

Area of Interest

Immunology, Cell biology and Microbiology

Research Experience

Dr. Dimpu Gogoi obtained his PhD from Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai under Homi Bhabha National Institute (HBNI) and completed his postdoctoral studies as a SERB Overseas PDF at the Institut Pasteur, France.

He started his independent research career as a DST ‘INSPIRE Faculty’ at ICMR-RMRCNE, Dibrugarh (2014-2019) where the focus of his research was to understand the role of T cell exhaustion in the pathogenesis of chronic hepatitis B and Plasmodium vivax infections. Dr. Dimpu Gogoi joined ICMR-NIRRCH, Mumbai as a Scientist ‘B’ in 2019 where he worked on immunopathology related to child and maternal health. He later returned to ICMR-RMRCNE, Dibrugarh in 2022; and has been working as a Scientist ‘C’ and Nodal Officer for MRHRU, Arunachal Pradesh.

Skilled in Flow cytometry, Cell culture techniques and Maintenance of primary as well as secondary mammalian cell lines, Transfection assay using siRNA, Immunomagnetic purification of T cell subsets, ELISA, SDS-PAGE, Western Blotting, PCR and Real Time PCR, Confocal microscopy, Cytotoxicity assay using 51Cr assay, Proliferation assays using tritiated thymidine and CFSE.

Research Interest

• Determining the therapeutic potential of immunoregulatory cells present in human breast milk.
• Understanding the fine tuning of T cell response that keeps the pathogen in check with minimal damage to self during infection.
• Investigating therapeutic strategies to overcome cancer progression and immune cell evasion by targeting the Notch ligand in both tumor cells and T infiltrating lymphocytes.

Awards & Acheivements

1. G.P. Talwar Young Scientist Award from the Indian Immunology Society.
2. Sam Mistry Travel Award to participate at ‘99th Annual Meeting of The American Association of Immunologists’, Boston, USA.
3. Top Downloaded Article among articles published in 2021 from Wiley publisher, 2023.
4. Covid Yodha Sammanpatra at ICMR-National Institute for Research in Reproductive & Child Health, Mumbai, 2021.
5. 1st prize for Oral presentation at ‘National Research Scholar Meet', ACTREC, Navi Mumbai.
6. 1st prize for Oral presentation at ‘37th Foundation Day Celebration of RMRC Dibrugarh’, ICMR-RMRC NE, Dibrugarh.
7. Best Poster Award at ‘4th Life sciences Symposium on Recent Advances in immunomodulation in Stress and Cancer’, 2008, BARC, Mumbai.
8. Best Poster Award at ‘National Research Scholar Meet', 2008, ACTREC, Navi Mumbai.

Professional Experience

Publications

1. Gogoi D*, Baruah PJ, Narain K. Immunopathology of emerging and re-emerging viral infections: an updated overview. Acta Virologica 2024 Apr. https://doi.org/10.3389/av.2024.12108 (IF: 0.8) [*Corresponding author]
2. Das M, Ojha AK, Dolma KG, Majumdar T, Sarmah P, Hazarika S, Modi M, Gogoi D, Das S and Ramamurthy T. Monitoring the potential dissemination of antimicrobial resistance in foods, environment, and clinical samples: a one health prospective. Food Science and Biotechnology 2024 August. https://doi.org/10.1007/s10068-024-01676-z (IF: 2.4)
3. Das M, Ojha AK, Sarmah P, Gogoi D, Dolma KG, Majumdar T, Hazarika SC, Modi D, Chowdhury G, Konwar C, Nath R, Das S & Ramamurthy T. Ethnic foods of Northeast India: insight into the light of food safety. BMC Public Health. 2024. (IF-3.6)
4. Sarmah P, Baruah PJ, Phukan C, Borkakoty B, Das M, Albert V, Ramamurthy T, Mahanta TG, Gogoi D, Dutta A, Das TK, Lahan M. An outbreak of acute diarrhoeal disease caused by Shigella sonnei in a village in Dibrugarh district, Assam. Indian J Med Res. 2024. (IF-2.7)
5. Albert V, Ramamurthy T, Das M, Das S, Ojha AK, Sarmah P, Gogoi D, Dolma KG, Majumdar T, Sarangthem I, Dutta T, Hazarika SC. Surveillance of Food and Waterborne Pathogens in North-East India: Protocol for a Laboratory-Based Sentinel Surveillance Study. JMIR Research Protocols. 2024. (IF-1.4)
6. Bhanothu V, Munne K, Pande S, Singh P, Jagtap D, Aranha C, Gogoi D, Bhagat S, Gaonkar R, Kerkar S, Shah K, Mukherjee N, Bhor V, Patel V, Mahale S, Sachdeva G and Begum S. The dynamics of SARS-CoV-2 infection in unvaccinated and vaccinated populations in Mumbai, India, between 28 December 2020 and 30 August 2021. Arch Virol. 2023 Jun; 23;168(7):188. (IF: 2.5)
7. Jawade K, Singh P, Begum S, Bhagat S, Gaonkar R, Kerkar S, Aranha C, Bhanothu V, Gogoi D, Shah K, Mukherjee N, Munne K, Pande S, Sachdeva G,Mahale S, Bhor V, Jagtap D and Patel V.Elevated Risk of COVID-19 Infection among People Living withHIV in Mumbai—A Retrospective Study. Re:GEN Open 2022 Jan; 2 (1):72-74.
8. Aranha C, Patel V, Bhor V and Gogoi D*. Cycle threshold values in RT-PCR to determine dynamics of SARS-CoV-2 viral load: An approach to reduce the isolation period for COVID-19 patients. J Med Virol. 2021 Dec;93 (12):6794-6797. (IF: 20.7) [*Corresponding author]
9. Gogoi D*, Borkakoty B, Biswas D, Yadav K and Patel V. Characteristics of Circulatory γδ T cells in Patients with Symptomatic Chronic Hepatitis B Infection. Viral Immunol. 2021 Sep;34(7):483-490. (IF: 2.2) [*First and corresponding author]
10. Chiplunkar SV and Gogoi D*. The multifaceted role of Notch signal in regulating T cell fate. Immunology Letters 2019; 206:59-64 (IF: 3.3) [*Corresponding author]
11. Gogoi D*, Biswas D, Borkakoty B and Mahanta J. Exposure to Plasmodium vivax is associated with the increased expression of exhaustion markers on γδ T lymphocytes. Parasite Immunology 2018; 40:e12594 (IF: 2.8) [*Corresponding author]
12. Dar AA, Bhat SA, Gogoi D and Chiplunkar SV. Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3+ αβ T-cells. Molecular Immunology 2017; 92:116-124 (IF: 3.2)
13. Gogoi D, Borkakoty B, Biswas D and Mahanta J. Activation and exhaustion of adaptive immune cells in hepatitis B infection. Viral Immunology 2015; Sep;28(7):348-53 (IF: 1.5).
14. Gogoi D, Dar AA and Chiplunkar SV. Involvement of Notch in activationand effector functions of gamma delta T cells. The Journal of Immunology 2014; 192(5):2054-62 (IF: 5.0).
15. Gogoi D and Chiplunkar SV. Targeting gamma delta T cells for cancer immunotherapy: bench to bedside.Indian Journal of Medical Research; 2013; 138(5):755-61 (IF: 1.7).

Book Chapters

• Gogoi D*, Biswas D, Borkakoty B and Mahanta J. Notch signal sand its emerging role in T cell biology. Spectrum 2016; 3:7-23, ISSN:2349 2937

Projects

Principal Investigator:

Title: Characterization of immunoregulatory cells in human breast milk and harnessing its potential therapeutic application in intestinal inflammation.

• Funding: ICMR (Intramural)
• Duration: 2024-2027
• Amount: ₹ 1,17,35,880.00

Title: Development of a sustainable network of laboratories in India for identification, monitoring, and research on virus and bacteria causing acute encephalitis syndrome and other novel pathogens through capacity building in advanced biomedical technologies

• Funding: PM-ABHIM
• Duration: 2023-2025
• Amount: ₹ 1,17,05,200.00

Title: Population-based Health Survey at Model Rural Health Research Unit (MRHRU)

• Funding: PM-ABHIM
• Duration: 2024-2026
• Amount: ₹ 6,78,000.00

Title: Surveillance of food borne pathogens from North East India

• Funding: ICMR (Extramural)
• Duration: 2023-2024
• Amount: ₹ 50,07,060.00

Title: Role of T cell exhaustion in conferring protection against cerebral malaria following T. gondi and P. berghei co-infection

• Funding: SERB
• Duration: 2017-2018
• Amount: ₹ 23,47,356.00

Title: Immune exhaustion in chronic hepatitis B and malaria: focus on γδ T cells

• Funding: DST
• Duration: 2014-2019
• Amount: ₹ 55,17,209.00

Staff